Version 5.4
Mus musculus Gene: Mesp2
Summary
InnateDB Gene IDBG-194351.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mesp2
Gene Name mesoderm posterior 2
Synonyms bHLHc6
Species Mus musculus
Ensembl Gene ENSMUSG00000030543
Encoded Proteins
IDBP-266779
mesoderm posterior 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188095:
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:79810727-79813431
Strand Forward strand
Band D2
Transcripts
ENSMUST00000107394 ENSMUSP00000103017
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001756 somitogenesis
GO:0007219 Notch signaling pathway
GO:0008078 mesodermal cell migration
GO:0023019 signal transduction involved in regulation of gene expression
GO:0032525 somite rostral/caudal axis specification
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000188095
View Gene Order
Cross-References
SwissProt
TrEMBL A6H5V4
UniProt Splice Variant
Entrez Gene 17293
UniGene Mm.31472 Mm.394824
RefSeq NM_008589
OMIM
CCDS CCDS39993
HPRD
IMGT
MGI ID MGI:1096325
MGI Symbol Mesp2
EMBL AC109221 BC145652 BC145654 CH466543
GenPept AAI45653 AAI45655 EDL07045
RNA Seq Atlas 17293

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca