Version 5.4
Mus musculus Gene: Arhgef25
Summary
InnateDB Gene IDBG-194400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef25
Gene Name Rho guanine nucleotide exchange factor (GEF) 25
Synonyms 2410008H17Rik; D10Ertd610e; GEFT
Species Mus musculus
Ensembl Gene ENSMUSG00000019467
Encoded Proteins
IDBP-194402
Rho guanine nucleotide exchange factor (GEF) 25
IDBP-620464
Rho guanine nucleotide exchange factor (GEF) 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000240771:
Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:127182521-127190054
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000019611 ENSMUSP00000019611
ENSMUST00000167353 ENSMUSP00000126339
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0030016 myofibril
GO:0030017 sarcomere
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000240771
View Gene Order
ENSBTAG00000018003
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
rhoa_reg_pathway
Regulation of RhoA activity
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL G5E825
UniProt Splice Variant
Entrez Gene 52666
UniGene Mm.399339
RefSeq NM_028027 XM_006513879 NM_001166413 XM_006513880
OMIM
CCDS CCDS24231 CCDS48715
HPRD
IMGT
MGI ID MGI:1277173
MGI Symbol Arhgef25
EMBL AC144852 CH466578
GenPept EDL24482
RNA Seq Atlas 52666

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca