Bos taurus Gene: GEFT | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-634956.3 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | GEFT | ||||||
Gene Name | rho guanine nucleotide exchange factor 25 | ||||||
Synonyms | GEFT | ||||||
Species | Bos taurus | ||||||
Ensembl Gene | ENSBTAG00000018003 | ||||||
Encoded Proteins |
Uncharacterized protein
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
Entrez Gene | |||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000240771:
Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 5:56205533-56212752 | ||||||
Strand | Forward strand | ||||||
Band | |||||||
Transcripts |
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Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
Species
Mus musculus
Homo sapiens
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||
NETPATH | |||||||
REACTOME |
GPCR downstream signaling pathway
Signaling by GPCR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
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KEGG | |||||||
INOH | |||||||
PID NCI |
Regulation of RAC1 activity
Regulation of RhoA activity
Regulation of CDC42 activity
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Cross-References | |||||||
SwissProt | |||||||
TrEMBL | F1MWU7 Q5EAB1 | ||||||
UniProt Splice Variant | |||||||
Entrez Gene | 506075 | ||||||
UniGene | Bt.3265 | ||||||
RefSeq | NM_001024481 XM_005206529 | ||||||
HUGO | |||||||
OMIM | |||||||
CCDS | |||||||
HPRD | |||||||
IMGT | |||||||
EMBL | BT020658 DAAA02013495 | ||||||
GenPept | AAX08675 | ||||||
RNA Seq Atlas | 506075 | ||||||