InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPP1R8

Summary

InnateDB Gene

IDBG-95029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R8

Gene Name

protein phosphatase 1, regulatory subunit 8

Synonyms

ARD-1; ARD1; NIPP-1; NIPP1; PRO2047

Species

Homo sapiens

Ensembl Gene

ENSG00000117751

Encoded Proteins

IDBP-95031

protein phosphatase 1, regulatory subunit 8

IDBP-95033

protein phosphatase 1, regulatory subunit 8

IDBP-95037

protein phosphatase 1, regulatory subunit 8

IDBP-377195

protein phosphatase 1, regulatory subunit 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:27830778-27851676

Strand

Forward strand

Band

p35.3

Transcripts

ENST00000311772	ENSP00000311677
ENST00000373931	ENSP00000363042
ENST00000236412	ENSP00000236412
ENST00000431586	ENSP00000410206
ENST00000486634

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0004865	protein serine/threonine phosphatase inhibitor activity
GO:0005515	protein binding
GO:0008599	protein phosphatase type 1 regulator activity
GO:0008995	ribonuclease E activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006401	RNA catabolic process
GO:0008283	cell proliferation
GO:0008380	RNA splicing
GO:0043086	negative regulation of catalytic activity
GO:0050790	regulation of catalytic activity
GO:0090501	RNA phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016607	nuclear speck

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028882

View Gene Order

ENSBTAG00000003866

Not yet available

Cross-References

SwissProt

Q12972

TrEMBL

Q6ICT4

UniProt Splice Variant

Entrez Gene

5511

UniGene

Hs.533474 Hs.618686

RefSeq

NM_002713 NM_014110 NM_138558 XM_006710723

HUGO

HGNC:9296

OMIM

602636

CCDS

CCDS311 CCDS312 CCDS313

HPRD

IMGT

EMBL

AF061958 AF061959 AF064751 AF064752 AF064753 AF064754 AF064755 AF064756 AF064757 AF126488 AK292077 AK297771 AK313814 AL020997 AL109927 BC001597 BC013360 CH471059 CR450309 U14575

GenPept

AAA64749 AAD22486 AAD24669 AAD24670 AAD31541 AAD31542 AAH01597 AAH13360 BAF84766 BAG36550 BAG60117 CAG29305 CAI20576 CAI20577 CAI20578 CAI21779 CAI21780 CAI21781 EAX07731 EAX07732 EAX07736

RNA Seq Atlas

5511