InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fer

Summary

InnateDB Gene

IDBG-194638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fer

Gene Name

fer (fms/fps related) protein kinase

Synonyms

AV082135; C330004K01Rik; Fer; Fert

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000127

Encoded Proteins

IDBP-194640

fer (fms/fps related) protein kinase

IDBP-194642

fer (fms/fps related) protein kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23355730

FER is an inhibitory kinase for neutrophil chemotaxis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151422:
Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:63896018-64139494

Strand

Forward strand

Band

E1.1

Transcripts

ENSMUST00000000129	ENSMUSP00000000129
ENSMUST00000038080	ENSMUSP00000037418

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008092	cytoskeletal protein binding
GO:0008157	protein phosphatase 1 binding
GO:0008289	lipid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017137	Rab GTPase binding
GO:0019901	protein kinase binding
GO:0045295	gamma-catenin binding
GO:0045296	cadherin binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001932	regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006935	chemotaxis
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0010591	regulation of lamellipodium assembly
GO:0010762	regulation of fibroblast migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0031532	actin cytoskeleton reorganization
GO:0032496	response to lipopolysaccharide
GO:0032869	cellular response to insulin stimulus
GO:0033007	negative regulation of mast cell activation involved in immune response
GO:0034446	substrate adhesion-dependent cell spreading
GO:0034614	cellular response to reactive oxygen species
GO:0035426	extracellular matrix-cell signaling
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0036119	response to platelet-derived growth factor stimulus
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038109	Kit signaling pathway
GO:0042058	regulation of epidermal growth factor receptor signaling pathway
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0044331	cell-cell adhesion mediated by cadherin
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050904	diapedesis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070102	interleukin-6-mediated signaling pathway

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane