Version 5.4
| Mus musculus Gene: Rfc5 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-194883.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Rfc5 | ||||||||||||||||||||||
| Gene Name | replication factor C (activator 1) 5 | ||||||||||||||||||||||
| Synonyms | 2610020K06Rik; 2610209F07Rik; 36.5kDa; 36kDa; Recc5 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000029363 | ||||||||||||||||||||||
| Encoded Proteins |
replication factor C (activator 1) 5
replication factor C (activator 1) 5
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111445:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 5:117378103-117389047 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | F | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Transcription-coupled NER (TC-NER) pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
DNA strand elongation pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
DNA Replication pathway
Global Genomic NER (GG-NER) pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Telomere Maintenance pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
Cell Cycle Checkpoints pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
DNA Repair pathway
Leading Strand Synthesis pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
G2/M Checkpoints pathway
Extension of Telomeres pathway
Polymerase switching pathway
Activation of ATR in response to replication stress pathway
Lagging Strand Synthesis pathway
Polymerase switching on the C-strand of the telomere pathway
S Phase pathway
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| KEGG |
DNA replication pathway
Nucleotide excision repair pathway
Mismatch repair pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Activation of ATR in response to replication stress pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Polymerase switching pathway
Leading Strand Synthesis pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
DNA Replication pathway
Synthesis of DNA pathway
S Phase pathway
Chromosome Maintenance pathway
G2/M Checkpoints pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
DNA Repair pathway
Cell Cycle Checkpoints pathway
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| KEGG |
DNA replication pathway
Nucleotide excision repair pathway
Mismatch repair pathway
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| INOH | |||||||||||||||||||||||
| PID NCI |
Fanconi anemia pathway
ATR signaling pathway
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| Cross-References | |||||||||||||||||||||||
| SwissProt | Q9D0F6 | ||||||||||||||||||||||
| TrEMBL | D3Z1Y6 Q5HZI8 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 72151 | ||||||||||||||||||||||
| UniGene | Mm.27997 Mm.406321 Mm.490633 | ||||||||||||||||||||||
| RefSeq | NM_028128 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS39235 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:1919401 | ||||||||||||||||||||||
| MGI Symbol | Rfc5 | ||||||||||||||||||||||
| EMBL | AC113299 AK011489 AK170211 BC089001 CH466529 | ||||||||||||||||||||||
| GenPept | AAH89001 BAB27652 BAE41638 EDL19804 | ||||||||||||||||||||||
| RNA Seq Atlas | 72151 | ||||||||||||||||||||||