InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RFC5

Summary

InnateDB Gene

IDBG-59633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFC5

Gene Name

replication factor C (activator 1) 5, 36.5kDa

Synonyms

RFC36

Species

Homo sapiens

Ensembl Gene

ENSG00000111445

Encoded Proteins

IDBP-245450

replication factor C (activator 1) 5, 36.5kDa

IDBP-383905

replication factor C (activator 1) 5, 36.5kDa

IDBP-383907

replication factor C (activator 1) 5, 36.5kDa

IDBP-383908

replication factor C (activator 1) 5, 36.5kDa

IDBP-595019

replication factor C (activator 1) 5, 36.5kDa

IDBP-592026

replication factor C (activator 1) 5, 36.5kDa

IDBP-584905

replication factor C (activator 1) 5, 36.5kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:118013588-118033130

Strand

Forward strand

Band

q24.23

Transcripts

ENST00000392542	ENSP00000376325
ENST00000454402	ENSP00000408295
ENST00000420967	ENSP00000390340
ENST00000449641	ENSP00000393636
ENST00000484086	ENSP00000445917
ENST00000472603
ENST00000537315	ENSP00000443187
ENST00000535092	ENSP00000438252
ENST00000543153

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	51 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0019899	enzyme binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0006260	DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0006310	DNA recombination
GO:0032201	telomere maintenance via semi-conservative replication