Version 5.4
Bos taurus Gene: RFC5
Summary
InnateDB Gene IDBG-633485.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFC5
Gene Name replication factor C subunit 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007137
Encoded Proteins
IDBP-685198
replication factor C subunit 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111445:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:59438187-59448907
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009392 ENSBTAP00000009392
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
Cellular Component
GO:0005663 DNA replication factor C complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111445
View Gene Order
ENSMUSG00000029363
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_7987
Polymerase switching on the C-strand of the telomere pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_1792
Polymerase switching pathway
REACT_1838
Leading Strand Synthesis pathway
REACT_1993
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_378
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_828
G2/M Checkpoints pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_202316
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_233453
Chromosome Maintenance pathway
REACT_258062
Synthesis of DNA pathway
REACT_241296
DNA strand elongation pathway
REACT_219381
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_232628
DNA Replication pathway
REACT_238177
Global Genomic NER (GG-NER) pathway
REACT_237585
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_252672
Telomere Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_209299
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_233397
DNA Repair pathway
REACT_259967
Leading Strand Synthesis pathway
REACT_220175
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_235397
G2/M Checkpoints pathway
REACT_252545
Extension of Telomeres pathway
REACT_245471
Polymerase switching pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_245263
Lagging Strand Synthesis pathway
REACT_225604
Polymerase switching on the C-strand of the telomere pathway
REACT_253623
S Phase pathway
KEGG
hsa03030
DNA replication pathway
hsa03420
Nucleotide excision repair pathway
hsa03430
Mismatch repair pathway
mmu03030
DNA replication pathway
mmu03420
Nucleotide excision repair pathway
mmu03430
Mismatch repair pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.100292 Bt.21988
RefSeq NM_001075358
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca