InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp2a3

Summary

InnateDB Gene

IDBG-197283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp2a3

Gene Name

ATPase, Ca++ transporting, ubiquitous

Synonyms

Serca3; SERCA3b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020788

Encoded Proteins

IDBP-197285

ATPase, Ca++ transporting, ubiquitous

IDBP-264428

ATPase, Ca++ transporting, ubiquitous

IDBP-264430

ATPase, Ca++ transporting, ubiquitous

IDBP-264432

ATPase, Ca++ transporting, ubiquitous

IDBP-626284

ATPase, Ca++ transporting, ubiquitous

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074370:
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:72961169-72993044

Strand

Forward strand

Band

Transcripts

ENSMUST00000021142	ENSMUSP00000021142
ENSMUST00000108486	ENSMUSP00000104126
ENSMUST00000108485	ENSMUSP00000104125
ENSMUST00000108484	ENSMUSP00000104124
ENSMUST00000149493
ENSMUST00000135234
ENSMUST00000163326	ENSMUSP00000127036

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0008152	metabolic process
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0031965	nuclear membrane
GO:0033017	sarcoplasmic reticulum membrane