Version 5.4
Bos taurus Gene: BT.62377
Summary
InnateDB Gene IDBG-633443.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.62377
Gene Name sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014806
Encoded Proteins
IDBP-685158
sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074370:
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:25163841-25198117
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019703 ENSBTAP00000019703
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005388 calcium-transporting ATPase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0008152 metabolic process
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000074370
View Gene Order
ENSMUSG00000020788
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23765
Reduction of cytosolic Ca++ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_25149
Ion transport by P-type ATPases pathway
REACT_118798
Pre-NOTCH Processing in Golgi pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_111102
Signal Transduction pathway
REACT_25300
Ion channel transport pathway
REACT_299
Signaling by NOTCH pathway
REACT_604
Hemostasis pathway
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_215282
Platelet calcium homeostasis pathway
REACT_247905
Reduction of cytosolic Ca++ levels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_250224
Ion transport by P-type ATPases pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa04020
Calcium signaling pathway pathway
hsa04972
Pancreatic secretion pathway
mmu04020
Calcium signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04972
Pancreatic secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BMQ6
UniProt Splice Variant
Entrez Gene 512313
UniGene Bt.62377
RefSeq NM_001114154
HUGO HGNC:813
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02048693 DAAA02048694
GenPept
RNA Seq Atlas 512313

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca