Version 5.4
| Mus musculus Gene: Gnai2 | |||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-198032.6 | ||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||
| Gene Symbol | Gnai2 | ||||||||||||||||||||||||||||||||
| Gene Name | guanine nucleotide binding protein (G protein), alpha inhibiting 2 | ||||||||||||||||||||||||||||||||
| Synonyms | C76432; Galphai2; Gia; Gnai-2 | ||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000032562 | ||||||||||||||||||||||||||||||||
| Encoded Proteins |
guanine nucleotide binding protein (G protein), alpha inhibiting 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||||
| Summary |
Gnai2 is regulated by Tlr signaling and plays an anti-inflammatory role in endotoxema and polymicrobial sepsis.
Sustained activation of Gnai2 dampens Tnf and Il6 production stimulated by Tlr2/4 ligands.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] GNAI2 is regulated by TLR signalling and plays an anti-inflammatory role in endotoxema and polymicrobial sepsis. (Demonstrated in murine model)
[Homo sapiens] Sustained activation of GNAI2 dampens TNF and IL6 production stimulated by TLR2/4 ligands. (Demonstrated in mice)
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| Entrez Gene | |||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114353:
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far. [provided by RefSeq, Oct 2009] The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
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| Gene Information | |||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 9:107614138-107635342 | ||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||
| Band | F1 | ||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||
| REACTOME |
G alpha (s) signalling events pathway
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Integration of energy metabolism pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Adenylate cyclase inhibitory pathway pathway
Metabolism pathway
Platelet activation, signaling and aggregation pathway
Activation of GABAB receptors pathway
Regulation of insulin secretion pathway
Inhibition of adenylate cyclase pathway pathway
G-protein activation pathway
ADP signalling through P2Y purinoceptor 12 pathway
GABA B receptor activation pathway
G alpha (z) signalling events pathway
GABA receptor activation pathway
G alpha (i) signalling events pathway
Neuronal System pathway
Opioid Signalling pathway
Signal Transduction pathway
Transmission across Chemical Synapses pathway
PLC beta mediated events pathway
Signal amplification pathway
G-protein mediated events pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
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| KEGG |
Tight junction pathway
Axon guidance pathway
Melanogenesis pathway
Gap junction pathway
Leukocyte transendothelial migration pathway
Long-term depression pathway
Parkinson's disease pathway
Chemokine signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Gastric acid secretion pathway
Toxoplasmosis pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||
| NETPATH |
TSH pathway
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| REACTOME |
ADP signalling through P2Y purinoceptor 12 pathway
G alpha (i) signalling events pathway
G alpha (s) signalling events pathway
G alpha (z) signalling events pathway
Adenylate cyclase inhibitory pathway pathway
PLC beta mediated events pathway
G-protein activation pathway
Opioid Signalling pathway
GABA B receptor activation pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
Neuronal System pathway
Signaling by GPCR pathway
GABA receptor activation pathway
Platelet activation, signaling and aggregation pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inhibition of adenylate cyclase pathway pathway
Signal amplification pathway
Hemostasis pathway
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| KEGG |
Gap junction pathway
Axon guidance pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Long-term depression pathway
Melanogenesis pathway
Parkinson's disease pathway
Chemokine signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Gastric acid secretion pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
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| INOH |
GPCR signaling pathway
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| PID NCI |
Thromboxane A2 receptor signaling
IL8- and CXCR2-mediated signaling events
IL8- and CXCR1-mediated signaling events
CXCR3-mediated signaling events
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| Cross-References | |||||||||||||||||||||||||||||||||
| SwissProt | P08752 | ||||||||||||||||||||||||||||||||
| TrEMBL | Q922Y6 | ||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||
| Entrez Gene | 14678 | ||||||||||||||||||||||||||||||||
| UniGene | Mm.196464 | ||||||||||||||||||||||||||||||||
| RefSeq | NM_008138 XM_006511637 | ||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||
| CCDS | CCDS23502 | ||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||
| MGI ID | MGI:95772 | ||||||||||||||||||||||||||||||||
| MGI Symbol | Gnai2 | ||||||||||||||||||||||||||||||||
| EMBL | AK157998 AK159222 AK167388 BC006695 BC065159 M13963 S71213 | ||||||||||||||||||||||||||||||||
| GenPept | AAA37692 AAB30632 AAH06695 AAH65159 BAE34308 BAE34909 BAE39478 | ||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 14678 | ||||||||||||||||||||||||||||||||