Version 5.4
Bos taurus Gene: GNAI2
Summary
InnateDB Gene IDBG-645836.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNAI2
Gene Name guanine nucleotide-binding protein G(i) subunit alpha-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020645
Encoded Proteins
IDBP-698590
guanine nucleotide-binding protein G(i) subunit alpha-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21255617
[Homo sapiens] GNAI2 is regulated by TLR signalling and plays an anti-inflammatory role in endotoxema and polymicrobial sepsis. (Demonstrated in murine model)
PMID 22581266
[Homo sapiens] Sustained activation of GNAI2 dampens TNF and IL6 production stimulated by TLR2/4 ligands. (Demonstrated in mice)
PMID 21255617
[Mus musculus] Gnai2 is regulated by Tlr signaling and plays an anti-inflammatory role in endotoxema and polymicrobial sepsis.
PMID 22581266
[Mus musculus] Sustained activation of Gnai2 dampens Tnf and Il6 production stimulated by Tlr2/4 ligands.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114353:
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far. [provided by RefSeq, Oct 2009]
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50670852-50691007
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027511 ENSBTAP00000027511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 56 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0001973 adenosine receptor signaling pathway
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0008283 cell proliferation
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030496 midbody
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000114353
View Gene Order
ENSMUSG00000032562
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_20653
ADP signalling through P2Y purinoceptor 12 pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_15333
Adenylate cyclase inhibitory pathway pathway
REACT_15426
PLC beta mediated events pathway
REACT_15457
G-protein activation pathway
REACT_15295
Opioid Signalling pathway
REACT_25031
GABA B receptor activation pathway
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_25199
GABA receptor activation pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_15526
G-protein mediated events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_25282
Inhibition of adenylate cyclase pathway pathway
REACT_20524
Signal amplification pathway
REACT_604
Hemostasis pathway
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_217323
Integration of energy metabolism pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_222824
Adenylate cyclase inhibitory pathway pathway
REACT_188937
Metabolism pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_207065
Activation of GABAB receptors pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_217338
Inhibition of adenylate cyclase pathway pathway
REACT_205726
G-protein activation pathway
REACT_232481
ADP signalling through P2Y purinoceptor 12 pathway
REACT_217868
GABA B receptor activation pathway
REACT_258013
G alpha (z) signalling events pathway
REACT_224131
GABA receptor activation pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_259290
Neuronal System pathway
REACT_242845
Opioid Signalling pathway
REACT_188257
Signal Transduction pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_253342
PLC beta mediated events pathway
REACT_251507
Signal amplification pathway
REACT_248370
G-protein mediated events pathway
REACT_250590
Adrenaline,noradrenaline inhibits insulin secretion pathway
KEGG
hsa04540
Gap junction pathway
hsa04360
Axon guidance pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04730
Long-term depression pathway
hsa04916
Melanogenesis pathway
hsa05012
Parkinson's disease pathway
hsa04062
Chemokine signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04971
Gastric acid secretion pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05145
Toxoplasmosis pathway
mmu04530
Tight junction pathway
mmu04360
Axon guidance pathway
mmu04916
Melanogenesis pathway
mmu04540
Gap junction pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04730
Long-term depression pathway
mmu05012
Parkinson's disease pathway
mmu04062
Chemokine signaling pathway pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04971
Gastric acid secretion pathway
mmu05145
Toxoplasmosis pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
GPCR signaling pathway
INOH website
GPCR signaling pathway
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
cxcr3pathway
CXCR3-mediated signaling events
Cross-References
SwissProt
TrEMBL A7MBH9 Q95KM8
UniProt Splice Variant
Entrez Gene 281791
UniGene Bt.4311
RefSeq NM_001101040
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF354744 BC151571 DAAA02054413
GenPept AAI51572 AAK49966
RNA Seq Atlas 281791

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca