InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dgka

Summary

InnateDB Gene

IDBG-198283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgka

Gene Name

diacylglycerol kinase, alpha

Synonyms

80kDa; AW146112; Dagk1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025357

Encoded Proteins

IDBP-198285

diacylglycerol kinase, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065357:
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:128720141-128744056

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026414

ENSMUSP00000026414

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005509	calcium ion binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016310	phosphorylation
GO:0035556	intracellular signal transduction