Version 5.4
Homo sapiens Gene: FKBP6
Summary
InnateDB Gene IDBG-19838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP6
Gene Name FK506 binding protein 6, 36kDa
Synonyms FKBP36
Species Homo sapiens
Ensembl Gene ENSG00000077800
Encoded Proteins
IDBP-19842
FK506 binding protein 6, 36kDa
IDBP-377504
FK506 binding protein 6, 36kDa
IDBP-377505
FK506 binding protein 6, 36kDa
IDBP-377507
FK506 binding protein 6, 36kDa
IDBP-377509
FK506 binding protein 6, 36kDa
IDBP-377510
FK506 binding protein 6, 36kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein may have cis-trans prolyl isomerase activity, and binds to clathrin heavy chain and heat shock protein 72. This gene is found to be deleted in Williams syndrome, and the orthologous gene in mouse is essential for fertility and homologous pairing in male meiosis. [provided by RefSeq, Sep 2008]
The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:73328164-73358637
Strand Forward strand
Band q11.23
Transcripts
ENST00000252037 ENSP00000252037
ENST00000437013
ENST00000431982 ENSP00000416277
ENST00000442793 ENSP00000402360
ENST00000413573 ENSP00000394952
ENST00000445032 ENSP00000415891
ENST00000429879 ENSP00000403908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0007126 meiotic nuclear division
GO:0007283 spermatogenesis
GO:0018208 peptidyl-proline modification
GO:0030154 cell differentiation
GO:0031047 gene silencing by RNA
GO:0034587 piRNA metabolic process
GO:0043046 DNA methylation involved in gamete generation
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0000795 synaptonemal complex
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040013
View Gene Order
ENSBTAG00000002253
Not yet available
Pathways
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8WD38
UniProt Splice Variant
Entrez Gene 8468
UniGene Hs.661266
RefSeq NM_001135211 NM_001281304 NM_003602 XM_006716152
HUGO HGNC:3722
OMIM 604839
CCDS CCDS43595 CCDS47604 CCDS64670
HPRD 05326
IMGT
EMBL AC005049 AC073841
GenPept
RNA Seq Atlas 8468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca