Version 5.4
Mus musculus Gene: Fkbp6
Summary
InnateDB Gene IDBG-203707.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fkbp6
Gene Name FK506 binding protein 6
Synonyms 1700008G22Rik; 36kDa; AU017274; D5Ertd724e; FKBP-36; FKBP-6
Species Mus musculus
Ensembl Gene ENSMUSG00000040013
Encoded Proteins
IDBP-203711
FK506 binding protein 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the FK506-binding protein (Fkbp) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to Hsp90 as a co-chaperone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:135291704-135349991
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000044972 ENSMUSP00000043193
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0007126 meiotic nuclear division
GO:0007283 spermatogenesis
GO:0018208 peptidyl-proline modification
GO:0030154 cell differentiation
GO:0031047 gene silencing by RNA
GO:0034587 piRNA metabolic process
GO:0043046 DNA methylation involved in gamete generation
Cellular Component
GO:0000795 synaptonemal complex
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000077800
View Gene Order
ENSBTAG00000002253
Not yet available
Pathways
NETPATH
REACTOME
REACT_75800
Meiotic Synapsis pathway
REACT_200794
Mus musculus biological processes pathway
REACT_198626
Meiotic synapsis pathway
REACT_188804
Cell Cycle pathway
REACT_198624
Meiosis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q91XW8
TrEMBL Q8CF43
UniProt Splice Variant
Entrez Gene 94244
UniGene Mm.26037
RefSeq NM_001277891 NM_033571 XM_006504534 XM_006504535
OMIM
CCDS CCDS19738
HPRD
IMGT
MGI ID MGI:2137612
MGI Symbol Fkbp6
EMBL AC074359 AF367709 AF367710 AF367711 AK005766 AK090036 AY029192 BC139092 BC139097 CH466529
GenPept AAI39093 AAI39098 AAK39645 AAK53411 AAK53412 AAK53413 BAC25125 BAC41058 EDL19373 EDL19374
RNA Seq Atlas 94244

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca