InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FKBP6

Summary

InnateDB Gene

IDBG-640067.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FKBP6

Gene Name

Peptidyl-prolyl cis-trans isomerase FKBP6

Synonyms

FKBP-6

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002253

Encoded Proteins

IDBP-692275

Peptidyl-prolyl cis-trans isomerase FKBP6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077800:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein may have cis-trans prolyl isomerase activity, and binds to clathrin heavy chain and heat shock protein 72. This gene is found to be deleted in Williams syndrome, and the orthologous gene in mouse is essential for fertility and homologous pairing in male meiosis. [provided by RefSeq, Sep 2008]
The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:34290739-34312807

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002909

ENSBTAP00000002909

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0007126	meiotic nuclear division
GO:0007283	spermatogenesis
GO:0018208	peptidyl-proline modification
GO:0030154	cell differentiation
GO:0031047	gene silencing by RNA
GO:0034587	piRNA metabolic process
GO:0043046	DNA methylation involved in gamete generation
GO:0061077	chaperone-mediated protein folding