Version 5.4
Mus musculus Gene: Eed
Summary
InnateDB Gene IDBG-198609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eed
Gene Name embryonic ectoderm development
Synonyms ENSMUSG00000039373; l(7)5Rn; l7Rn5; lusk
Species Mus musculus
Ensembl Gene ENSMUSG00000030619
Encoded Proteins
IDBP-267117
embryonic ectoderm development
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074266:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:89954656-89980983
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000107234 ENSMUSP00000102853
ENSMUST00000157001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1175 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Experimentally validated
Total 1175 [view]
Protein-Protein 1175 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0042054 histone methyltransferase activity
GO:0042802 identical protein binding
Biological Process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016571 histone methylation
GO:0061087 positive regulation of histone H3-K27 methylation
Cellular Component
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0035098 ESC/E(Z) complex
GO:0045120 pronucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000074266
View Gene Order
ENSBTAG00000007847
Not yet available
Pathways
NETPATH
REACTOME
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_188957
Cellular responses to stress pathway
REACT_222475
PRC2 methylates histones and DNA pathway
REACT_188820
Cellular Senescence pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_233572
Gene Expression pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_213048
Epigenetic regulation of gene expression pathway
REACT_206069
Cellular responses to stress pathway
REACT_226022
Gene Expression pathway
REACT_215025
Cellular Senescence pathway
REACT_225657
Oxidative Stress Induced Senescence pathway
REACT_207393
PRC2 methylates histones and DNA pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.380914
RefSeq NM_021876
OMIM
CCDS CCDS40016
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca