InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EED

Summary

InnateDB Gene

IDBG-641921.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EED

Gene Name

Polycomb protein EED

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007847

Encoded Proteins

IDBP-694331

Polycomb protein EED

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074266:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:9325136-9355669

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000010324

ENSBTAP00000010324

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0042054	histone methyltransferase activity
GO:0042802	identical protein binding

Biological Process

GO:0006349	regulation of gene expression by genetic imprinting
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0016571	histone methylation
GO:0061087	positive regulation of histone H3-K27 methylation