Version 5.4
Homo sapiens Gene: EED
Summary
InnateDB Gene IDBG-66821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EED
Gene Name embryonic ectoderm development
Synonyms HEED; WAIT1
Species Homo sapiens
Ensembl Gene ENSG00000074266
Encoded Proteins
IDBP-66823
embryonic ectoderm development
IDBP-66825
embryonic ectoderm development
IDBP-66827
embryonic ectoderm development
IDBP-585315
embryonic ectoderm development
IDBP-592606
embryonic ectoderm development
IDBP-588510
embryonic ectoderm development
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:86244544-86278813
Strand Forward strand
Band q14.2
Transcripts
ENST00000327320 ENSP00000315587
ENST00000351625 ENSP00000338186
ENST00000263360 ENSP00000263360
ENST00000528180 ENSP00000431778
ENST00000534595 ENSP00000436084
ENST00000525244
ENST00000533228
ENST00000534564
ENST00000524673
ENST00000527888 ENSP00000437318
ENST00000528250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 513 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 513 [view]
Protein-Protein 510 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0042054 histone methyltransferase activity
GO:0042802 identical protein binding
Biological Process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0016571 histone methylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0061087 positive regulation of histone H3-K27 methylation
Cellular Component
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0035098 ESC/E(Z) complex
GO:0045120 pronucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030619
View Gene Order
ENSBTAG00000007847
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O75530
TrEMBL E9PJK2 E9PMU3
UniProt Splice Variant
Entrez Gene 8726
UniGene Hs.503510
RefSeq NM_003797 NM_152991 XM_005274373 XM_006718731
HUGO HGNC:3188
OMIM 605984
CCDS CCDS8273 CCDS8274
HPRD
IMGT
EMBL AF070418 AF078933 AF080227 AF099032 AK292120 AP003084 BC047672 BC068995 CH471076 U90651
GenPept AAC23685 AAC68675 AAC95144 AAD08714 AAD08815 AAH47672 AAH68995 BAF84809 EAW75129 EAW75130
RNA Seq Atlas 8726

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca