Version 5.4
Mus musculus Gene: Picalm
Summary
InnateDB Gene IDBG-198693.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Picalm
Gene Name phosphatidylinositol binding clathrin assembly protein
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000039361
Encoded Proteins
IDBP-198695
phosphatidylinositol binding clathrin assembly protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073921:
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:90130232-90209447
Strand Forward strand
Band D3
Transcripts
ENSMUST00000049537 ENSMUSP00000051092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005545 1-phosphatidylinositol binding
GO:0030276 clathrin binding
GO:0032050 clathrin heavy chain binding
GO:0035615 clathrin adaptor activity
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0007409 axonogenesis
GO:0008283 cell proliferation
GO:0010629 negative regulation of gene expression
GO:0016188 synaptic vesicle maturation
GO:0016197 endosomal transport
GO:0030097 hemopoiesis
GO:0030100 regulation of endocytosis
GO:0031623 receptor internalization
GO:0032880 regulation of protein localization
GO:0035459 cargo loading into vesicle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0048268 clathrin coat assembly
GO:0048813 dendrite morphogenesis
GO:0055072 iron ion homeostasis
GO:0072583 clathrin-mediated endocytosis
GO:0097459 iron ion import into cell
GO:1901216 positive regulation of neuron death
GO:1902004 positive regulation of beta-amyloid formation
GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005905 coated pit
GO:0016020 membrane
GO:0030122 AP-2 adaptor complex
GO:0030132 clathrin coat of coated pit
GO:0031982 vesicle
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0097418 neurofibrillary tangle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000073921
View Gene Order
ENSBTAG00000001657
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q7M6Y3
TrEMBL
UniProt Splice Variant
Entrez Gene 233489
UniGene Mm.235175 Mm.427539
RefSeq NM_001252520 NM_001252521 NM_001252522 NM_001252523 NM_001252524 NM_146194
OMIM
CCDS CCDS52307
HPRD
IMGT
MGI ID MGI:2385902
MGI Symbol Picalm
EMBL AK085472 AK162360 AY206701 BC011470 BC021491 BC023843 BC025566 BC027116 BC057683 BK001028
GenPept AAH11470 AAH21491 AAH23843 AAH25566 AAH27116 AAH57683 AAO17153 BAC39454 BAE36872 DAA01470
RNA Seq Atlas 233489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca