Version 5.4
| Mus musculus Gene: Gab2 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-199566.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Gab2 | ||||||||||||||||||||||
| Gene Name | growth factor receptor bound protein 2-associated protein 2 | ||||||||||||||||||||||
| Synonyms | AI463667; D130058I17Rik; p97 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000004508 | ||||||||||||||||||||||
| Encoded Proteins |
growth factor receptor bound protein 2-associated protein 2
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000033327:
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 7:97081751-97308940 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | E1 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME | |||||||||||||||||||||||
| KEGG |
Fc epsilon RI signaling pathway pathway
Chronic myeloid leukemia pathway
Fc gamma R-mediated phagocytosis pathway
Osteoclast differentiation pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL6 pathway
RANKL pathway
TSLP pathway
Prolactin pathway
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| REACTOME |
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
GPVI-mediated activation cascade pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by SCF-KIT pathway
Signaling by FGFR1 fusion mutants pathway
Signaling by FGFR mutants pathway
Signaling by FGFR in disease pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by FGFR1 mutants pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
Signaling by Interleukins pathway
Disease pathway
Hemostasis pathway
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| KEGG |
Fc epsilon RI signaling pathway pathway
Chronic myeloid leukemia pathway
Fc gamma R-mediated phagocytosis pathway
Osteoclast differentiation pathway
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| INOH | |||||||||||||||||||||||
| PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL2-mediated signaling events
TCR signaling in naïve CD4+ T cells
Neurotrophic factor-mediated Trk receptor signaling
IL3-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
GMCSF-mediated signaling events
Fc-epsilon receptor I signaling in mast cells
IL2 signaling events mediated by PI3K
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | Q3ZB57 Q3ZB59 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 14389 | ||||||||||||||||||||||
| UniGene | Mm.42033 | ||||||||||||||||||||||
| RefSeq | NM_001162477 NM_010248 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS21455 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:1333854 | ||||||||||||||||||||||
| MGI Symbol | Gab2 | ||||||||||||||||||||||
| EMBL | AC074047 AC141638 AC155933 BC103524 BC103525 BC103526 | ||||||||||||||||||||||
| GenPept | AAI03525 AAI03526 AAI03527 | ||||||||||||||||||||||
| RNA Seq Atlas | 14389 | ||||||||||||||||||||||