Version 5.4
Bos taurus Gene: GAB2
Summary
InnateDB Gene IDBG-642116.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAB2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002922
Encoded Proteins
IDBP-694539
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000033327:
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:17833137-17887917
Strand Forward strand
Band
Transcripts
ENSBTAT00000003794 ENSBTAP00000003794
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007229 integrin-mediated signaling pathway
GO:0016477 cell migration
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000033327
View Gene Order
ENSMUSG00000004508
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_24
TSLP pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_121141
Signaling by FGFR1 fusion mutants pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_120999
Signaling by FGFR1 mutants pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04380
Osteoclast differentiation pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu05220
Chronic myeloid leukemia pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04380
Osteoclast differentiation pathway
INOH
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
il2_1pathway
IL2-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
il3_pathway
IL3-mediated signaling events
shp2_pathway
SHP2 signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
gmcsf_pathway
GMCSF-mediated signaling events
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
il2_pi3kpathway
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL F1MFX6
UniProt Splice Variant
Entrez Gene 529346
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02062722
GenPept
RNA Seq Atlas 529346

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca