InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Usp4

Summary

InnateDB Gene

IDBG-199676.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp4

Gene Name

ubiquitin specific peptidase 4 (proto-oncogene)

Synonyms

F730026I20Rik; mKIAA4155; Unp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032612

Encoded Proteins

IDBP-199678

ubiquitin specific peptidase 4 (proto-oncogene)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22262844

Usp4 is a potent negative regulator of Tlr/Il1r-signalling through deubiquitination of Traf6 to prevent the activation of inflammatory responses.

InnateDB Annotation from Orthologs

Summary

PMID 22262844

[Homo sapiens] USP4 is a potent negative regulator of TLR/IL1Rsignalling through deubiquitination of TRAF6 to prevent activation of inflammatory responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114316:
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:108347831-108392529

Strand

Forward strand

Band

Transcripts

ENSMUST00000035237

ENSMUSP00000035237

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0031685	adenosine receptor binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016579	protein deubiquitination
GO:0031397	negative regulation of protein ubiquitination
GO:0031647	regulation of protein stability
GO:0034394	protein localization to cell surface
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000114316

View Gene Order

ENSBTAG00000011899

Not yet available

Cross-References

SwissProt

P35123

TrEMBL

Q3TPN5 Q3TQZ9

UniProt Splice Variant

Entrez Gene

22258

UniGene

Mm.3974 Mm.472812

RefSeq

NM_011678 XM_006511696

OMIM

CCDS

CCDS23523

HPRD

IMGT

MGI ID

MGI:98905

MGI Symbol

Usp4

EMBL

AF026469 AK089425 AK143582 AK149964 AK163201 AK164245 AK169933 AK171271 CH466560 L00681

GenPept

AAB82339 AAC53587 BAC40877 BAE25450 BAE29198 BAE37232 BAE37701 BAE41468 BAE42357 EDL21282

RNA Seq Atlas

22258