Version 5.4
Bos taurus Gene: USP4
Summary
InnateDB Gene IDBG-646000.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP4
Gene Name Ubiquitin carboxyl-terminal hydrolase 4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011899
Encoded Proteins
IDBP-698766
Ubiquitin carboxyl-terminal hydrolase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22262844
[Homo sapiens] USP4 is a potent negative regulator of TLR/IL1Rsignalling through deubiquitination of TRAF6 to prevent activation of inflammatory responses.
PMID 22262844
[Mus musculus] Usp4 is a potent negative regulator of Tlr/Il1r-signalling through deubiquitination of Traf6 to prevent the activation of inflammatory responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114316:
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:51335299-51374742
Strand Forward strand
Band
Transcripts
ENSBTAT00000015787 ENSBTAP00000015787
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.
Predicted by orthology
Total 67 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0031685 adenosine receptor binding
GO:0036459 ubiquitinyl hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
GO:0031397 negative regulation of protein ubiquitination
GO:0031647 regulation of protein stability
GO:0034394 protein localization to cell surface
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000114316
View Gene Order
ENSMUSG00000032612
View Gene Order
Cross-References
SwissProt A6QR55
TrEMBL
UniProt Splice Variant
Entrez Gene 508042
UniGene Bt.52457
RefSeq NM_001100319 XM_005222751
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC150120
GenPept AAI50121
RNA Seq Atlas 508042

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca