Version 5.4
Mus musculus Gene: Nckipsd
Summary
InnateDB Gene IDBG-200552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nckipsd
Gene Name NCK interacting protein with SH3 domain
Synonyms AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP; WISH
Species Mus musculus
Ensembl Gene ENSMUSG00000032598
Encoded Proteins
IDBP-200554
NCK interacting protein with SH3 domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213672:
The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:108808380-108818366
Strand Forward strand
Band F2
Transcripts
ENSMUST00000035218 ENSMUSP00000035218
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
Cellular Component
GO:0008180 COP9 signalosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000213672
View Gene Order
ENSBTAG00000021850
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_230745
Immune System pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9ESJ4
TrEMBL
UniProt Splice Variant
Entrez Gene 80987
UniGene Mm.192416
RefSeq NM_030729 XM_006511860
OMIM
CCDS CCDS23538
HPRD
IMGT
MGI ID MGI:1931834
MGI Symbol Nckipsd
EMBL AF130313 AK134725 BC064818 CH466560
GenPept AAF36503 AAH64818 BAE22259 EDL21315
RNA Seq Atlas 80987

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca