Version 5.4
Mus musculus Gene: Setd8
Summary
InnateDB Gene IDBG-200660.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Setd8
Gene Name SET domain containing (lysine methyltransferase) 8
Synonyms 2410195B05Rik; AA617402; AW536475; PR-SET7
Species Mus musculus
Ensembl Gene ENSMUSG00000049327
Encoded Proteins
IDBP-200662
SET domain containing (lysine methyltransferase) 8
IDBP-200664
SET domain containing (lysine methyltransferase) 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183955:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:124439930-124462308
Strand Forward strand
Band F
Transcripts
ENSMUST00000059580 ENSMUSP00000052953
ENSMUST00000100709 ENSMUSP00000098275
ENSMUST00000147969
ENSMUST00000134826
ENSMUST00000138766
ENSMUST00000154031
ENSMUST00000147692
ENSMUST00000143722
ENSMUST00000135667
ENSMUST00000125588
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0018024 histone-lysine N-methyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0018026 peptidyl-lysine monomethylation
GO:0034968 histone lysine methylation
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183955
View Gene Order
ENSBTAG00000000139
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.137966 Mm.405213 Mm.472072
RefSeq NM_030241 XM_006530448 XM_006530449 XM_006530450 XM_006530451
OMIM
CCDS CCDS19675
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca