InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnr

Summary

InnateDB Gene

IDBG-200901.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnr

Gene Name

tenascin R

Synonyms

J1-tenascin; janusin; restrictin; TN-R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015829

Encoded Proteins

IDBP-257628

tenascin R

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116147:
Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion; MIM 187380), TNX (TNXB; MIM 600985), and TNR (Erickson, 1993 [PubMed 7694605]). The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM, Mar 2008]
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:159737510-159924397

Strand

Forward strand

Band

Transcripts

ENSMUST00000111669

ENSMUSP00000107298

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046625	sphingolipid binding

Biological Process

GO:0007158	neuron cell-cell adhesion
GO:0008306	associative learning
GO:0010977	negative regulation of neuron projection development
GO:0022029	telencephalon cell migration
GO:0022408	negative regulation of cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0030517	negative regulation of axon extension
GO:0035641	locomotory exploration behavior
GO:0048692	negative regulation of axon extension involved in regeneration
GO:0050804	regulation of synaptic transmission
GO:0050805	negative regulation of synaptic transmission
GO:0050808	synapse organization
GO:0050885	neuromuscular process controlling balance
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0051971	positive regulation of transmission of nerve impulse
GO:0060291	long-term synaptic potentiation

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0045121	membrane raft
GO:0072534	perineuronal net

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000116147

View Gene Order

ENSBTAG00000011706

Not yet available

Pathways

NETPATH

REACTOME

REACT_206066

Extracellular matrix organization pathway

REACT_196606

ECM proteoglycans pathway

KEGG

mmu04512

ECM-receptor interaction pathway

mmu04510

Focal adhesion pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118779

Extracellular matrix organization pathway

REACT_163906

ECM proteoglycans pathway

KEGG

hsa04512

ECM-receptor interaction pathway

hsa04510

Focal adhesion pathway

INOH

PID NCI

Cross-References

SwissProt

Q8BYI9

TrEMBL

UniProt Splice Variant

Entrez Gene

21960

UniGene

Mm.44701

RefSeq

NM_022312 XM_006496742 XM_006496743 XM_006496744

OMIM

CCDS

CCDS15403

HPRD

IMGT

MGI ID

MGI:99516

MGI Symbol

Tnr

EMBL

AJ005844 AK039390 BC132392 BC138043

GenPept

AAI32393 AAI38044 BAC30335 CAA06739

RNA Seq Atlas

21960