InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TNR

Summary

InnateDB Gene

IDBG-636417.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNR

Gene Name

tenascin-R precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011706

Encoded Proteins

IDBP-688365

tenascin R (restrictin, janusin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116147:
Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion; MIM 187380), TNX (TNXB; MIM 600985), and TNR (Erickson, 1993 [PubMed 7694605]). The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM, Mar 2008]
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:58006950-58156083

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015545

ENSBTAP00000015545

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007158	neuron cell-cell adhesion
GO:0008306	associative learning
GO:0010977	negative regulation of neuron projection development
GO:0022029	telencephalon cell migration
GO:0022408	negative regulation of cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0030517	negative regulation of axon extension
GO:0035641	locomotory exploration behavior
GO:0048692	negative regulation of axon extension involved in regeneration
GO:0050804	regulation of synaptic transmission
GO:0050805	negative regulation of synaptic transmission
GO:0050808	synapse organization
GO:0050885	neuromuscular process controlling balance
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0051971	positive regulation of transmission of nerve impulse
GO:0060291	long-term synaptic potentiation

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0045121	membrane raft
GO:0072534	perineuronal net