InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pax7

Summary

InnateDB Gene

IDBG-201015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pax7

Gene Name

paired box gene 7

Synonyms

Pax-7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028736

Encoded Proteins

IDBP-201017

paired box gene 7

IDBP-626061

paired box gene 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000009709:
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:139737062-139833528

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030508	ENSMUSP00000030508
ENSMUST00000174681	ENSMUSP00000133536

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007519	skeletal muscle tissue development
GO:0009887	organ morphogenesis
GO:0010453	regulation of cell fate commitment
GO:0010468	regulation of gene expression
GO:0014813	satellite cell commitment
GO:0021527	spinal cord association neuron differentiation
GO:0021904	dorsal/ventral neural tube patterning
GO:0031062	positive regulation of histone methylation
GO:0043393	regulation of protein binding
GO:0043403	skeletal muscle tissue regeneration
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048663	neuron fate commitment
GO:0048706	embryonic skeletal system development
GO:0051216	cartilage development
GO:0060415	muscle tissue morphogenesis
GO:2000288	positive regulation of myoblast proliferation

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000009709

View Gene Order

ENSBTAG00000014967

Not yet available

Cross-References

SwissProt

TrEMBL

G3UX36 Q7TPG3

UniProt Splice Variant

Entrez Gene

18509

UniGene

Mm.218760 Mm.445608

RefSeq

NM_011039 XM_006538629 XM_006538630 XM_006538631

OMIM

CCDS

CCDS18850

HPRD

IMGT

MGI ID

MGI:97491

MGI Symbol

Pax7

EMBL

AL831790 AL844480 AY328081

GenPept

AAP92423

RNA Seq Atlas

18509