InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Socs5

Summary

InnateDB Gene

IDBG-201346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Socs5

Gene Name

suppressor of cytokine signaling 5

Synonyms

1810018L08Rik; Cish5; mKIAA0671

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037104

Encoded Proteins

IDBP-201348

suppressor of cytokine signaling 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 15590694

[Homo sapiens] SOCS4 and SOCS5 regulate EGFR signaling

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171150:
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:87107679-87137583

Strand

Forward strand

Band

Transcripts

ENSMUST00000041369

ENSMUSP00000038591

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0019210	kinase inhibitor activity
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0007259	JAK-STAT cascade
GO:0009968	negative regulation of signal transduction
GO:0016049	cell growth
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0045629	negative regulation of T-helper 2 cell differentiation

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000171150

View Gene Order

ENSBTAG00000008987

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04630

Jak-STAT signaling pathway pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_6

KitReceptor pathway

NetPath_16

IL4 pathway

REACTOME

KEGG

hsa04630

Jak-STAT signaling pathway pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

PID NCI

il4_2pathway

IL4-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.126885

RefSeq

NM_019654 XM_006524671 XM_006524672 XM_006524673 XM_006524674 XM_006524675

OMIM

CCDS

CCDS29014

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas