Version 5.4
Bos taurus Gene: BT.58314
Summary
InnateDB Gene IDBG-633338.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.58314
Gene Name suppressor of cytokine signaling 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008987
Encoded Proteins
IDBP-685033
suppressor of cytokine signaling 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 15590694
[Homo sapiens] SOCS4 and SOCS5 regulate EGFR signaling
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171150:
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:28985138-29053248
Strand Forward strand
Band
Transcripts
ENSBTAT00000011826 ENSBTAP00000011826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0007259 JAK-STAT cascade
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556 intracellular signal transduction
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0045629 negative regulation of T-helper 2 cell differentiation
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000171150
View Gene Order
ENSMUSG00000037104
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_16
IL4 pathway
REACTOME
KEGG
hsa04630
Jak-STAT signaling pathway pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
JAK STAT pathway and regulation pathway
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL F1MWV6
UniProt Splice Variant
Entrez Gene 514773
UniGene Bt.58314
RefSeq NM_001046182 XM_005212610 XM_005212611 XM_005212612
HUGO HGNC:16852
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030726 DAAA02030727
GenPept
RNA Seq Atlas 514773

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca