Version 5.4
Mus musculus Gene: Padi3
Summary
InnateDB Gene IDBG-201349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Padi3
Gene Name peptidyl arginine deiminase, type III
Synonyms AI507004; mKIAA4171; Pad3; Pdi3
Species Mus musculus
Ensembl Gene ENSMUSG00000025328
Encoded Proteins
IDBP-201351
peptidyl arginine deiminase, type III
IDBP-626351
peptidyl arginine deiminase, type III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142619:
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:140785365-140810648
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000026377 ENSMUSP00000026377
ENSMUST00000172098 ENSMUSP00000130721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
Biological Process
GO:0018101 protein citrullination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000142619
View Gene Order
ENSBTAG00000012043
Not yet available
Cross-References
SwissProt Q9Z184
TrEMBL
UniProt Splice Variant
Entrez Gene 18601
UniGene Mm.20851
RefSeq NM_011060
OMIM
CCDS CCDS18855
HPRD
IMGT
MGI ID MGI:1338891
MGI Symbol Padi3
EMBL AB013849 AL807805
GenPept BAA34182 CAM25733
RNA Seq Atlas 18601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca