Version 5.4
Bos taurus Gene: PADI3
Summary
InnateDB Gene IDBG-645801.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PADI3
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012043
Encoded Proteins
IDBP-698556
peptidyl arginine deiminase, type III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142619:
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:135891757-135920584
Strand Reverse strand
Band
Transcripts
ENSBTAT00000015978 ENSBTAP00000015978
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006464 cellular protein modification process
GO:0018101 protein citrullination
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000142619
View Gene Order
ENSMUSG00000025328
View Gene Order
Cross-References
SwissProt
TrEMBL E1BD46
UniProt Splice Variant
Entrez Gene 508160
UniGene Bt.112133
RefSeq XM_003581906 XM_003585802
HUGO HGNC:18337
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02006575
GenPept
RNA Seq Atlas 508160

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca