InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Klhl20

Summary

InnateDB Gene

IDBG-201411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klhl20

Gene Name

kelch-like 20 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026705

Encoded Proteins

IDBP-257751

kelch-like 20 (Drosophila)

IDBP-400349

kelch-like 20 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076321:
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:161088375-161131511

Strand

Reverse strand

Band

H2.1

Transcripts

ENSMUST00000111611	ENSMUSP00000107238
ENSMUST00000117467	ENSMUSP00000114044
ENSMUST00000140905
ENSMUST00000148952
ENSMUST00000145736

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0019964	interferon-gamma binding

Biological Process

GO:0006895	Golgi to endosome transport
GO:0016567	protein ubiquitination
GO:0043066	negative regulation of apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1990390	protein K33-linked ubiquitination

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0016605	PML body
GO:0031463	Cul3-RING ubiquitin ligase complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000076321

View Gene Order

ENSBTAG00000024485

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

ecadherin_nascentaj_pathway

E-cadherin signaling in the nascent adherens junction

Cross-References

SwissProt

Q8VCK5

TrEMBL

Q8BL42 Q8K2U3

UniProt Splice Variant

Entrez Gene

226541

UniGene

RefSeq

NM_001039482

OMIM

CCDS

CCDS35748

HPRD

IMGT

MGI ID

MGI:2444855

MGI Symbol

Klhl20

EMBL

AK046442 AK053102 AK220547 BC019571 BC029801

GenPept

AAH19571 AAH29801 BAC32731 BAC35266 BAD90319

RNA Seq Atlas

226541