Version 5.4
Bos taurus Gene: KLHL20
Summary
InnateDB Gene IDBG-636314.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL20
Gene Name Kelch-like protein 20
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000024485
Encoded Proteins
IDBP-688237
Kelch-like protein 20
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076321:
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:56552275-56623120
Strand Forward strand
Band
Transcripts
ENSBTAT00000034007 ENSBTAP00000033909
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0019964 interferon-gamma binding
Biological Process
GO:0006810 transport
GO:0006895 Golgi to endosome transport
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1990390 protein K33-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016605 PML body
GO:0030424 axon
GO:0030425 dendrite
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0042995 cell projection
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000076321
View Gene Order
ENSMUSG00000026705
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.33434
RefSeq NM_001076835 XM_005217060 XM_005217061 XM_005217062 XM_005217063
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca