InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: P2ry2

Summary

InnateDB Gene

IDBG-201761.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2ry2

Gene Name

purinergic receptor P2Y, G-protein coupled 2

Synonyms

P2U1; P2Y2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032860

Encoded Proteins

IDBP-201763

purinergic receptor P2Y, G-protein coupled 2

IDBP-722800

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175591:
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:100996572-101011991

Strand

Reverse strand

Band

Transcripts

ENSMUST00000037540	ENSMUSP00000036765
ENSMUST00000178340	ENSMUSP00000137152

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0045028	G-protein coupled purinergic nucleotide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0042312	regulation of vasodilation
GO:0070257	positive regulation of mucus secretion