InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: P2RY2

Summary

InnateDB Gene

IDBG-63697.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RY2

Gene Name

purinergic receptor P2Y, G-protein coupled, 2

Synonyms

HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R

Species

Homo sapiens

Ensembl Gene

ENSG00000175591

Encoded Proteins

IDBP-63699

purinergic receptor P2Y, G-protein coupled, 2

IDBP-243302

purinergic receptor P2Y, G-protein coupled, 2

IDBP-243304

purinergic receptor P2Y, G-protein coupled, 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:73218298-73236352

Strand

Forward strand

Band

q13.4

Transcripts

ENST00000311131	ENSP00000310305
ENST00000393597	ENSP00000377222
ENST00000393596	ENSP00000377221

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0045028	G-protein coupled purinergic nucleotide receptor activity

Biological Process

GO:0006873	cellular ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0042312	regulation of vasodilation
GO:0070257	positive regulation of mucus secretion