InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pde2a

Summary

InnateDB Gene

IDBG-202048.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde2a

Gene Name

phosphodiesterase 2A, cGMP-stimulated

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030653

Encoded Proteins

IDBP-202050

phosphodiesterase 2A, cGMP-stimulated

IDBP-625960

phosphodiesterase 2A, cGMP-stimulated

IDBP-625964

phosphodiesterase 2A, cGMP-stimulated

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186642:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:101421691-101512829

Strand

Forward strand

Band

Transcripts

ENSMUST00000084894	ENSMUSP00000081956
ENSMUST00000163751	ENSMUSP00000131553
ENSMUST00000166652	ENSMUSP00000127521

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0030552	cAMP binding
GO:0030553	cGMP binding
GO:0030911	TPR domain binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0019933	cAMP-mediated signaling
GO:0019934	cGMP-mediated signaling
GO:0030224	monocyte differentiation
GO:0033159	negative regulation of protein import into nucleus, translocation
GO:0035690	cellular response to drug
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0043116	negative regulation of vascular permeability
GO:0043117	positive regulation of vascular permeability
GO:0046069	cGMP catabolic process
GO:0071321	cellular response to cGMP
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000186642

View Gene Order

ENSBTAG00000008419

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00230

Purine metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_23767

cGMP effects pathway

REACT_23862

Nitric oxide stimulates guanylate cyclase pathway

REACT_23876

Platelet homeostasis pathway

REACT_19327

G alpha (s) signalling events pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_604

Hemostasis pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

Q5PR72

UniProt Splice Variant

Entrez Gene

207728

UniGene

Mm.247564

RefSeq

NM_001008548 NM_001143849 NM_001243757 NM_001243758 XM_006507523 XM_006507527 NM_001143848 XM_006507524 XM_006507525 XM_006507526 XM_006507528 XM_006507529

OMIM

CCDS

CCDS40043 CCDS52330

HPRD

IMGT

MGI ID

MGI:2446107

MGI Symbol

Pde2a

EMBL

AC129079 AC129609 BC086800

GenPept

AAH86800

RNA Seq Atlas

207728