InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDE2A

Summary

InnateDB Gene

IDBG-635129.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE2A

Gene Name

cGMP-dependent 3',5'-cyclic phosphodiesterase

Synonyms

CGS-PDE; cGSPDE

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008419

Encoded Proteins

IDBP-686991

cGMP-dependent 3',5'-cyclic phosphodiesterase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186642:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:52913333-52984107

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000011077

ENSBTAP00000011077

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0008144	drug binding
GO:0016787	hydrolase activity
GO:0030552	cAMP binding
GO:0030553	cGMP binding
GO:0030911	TPR domain binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0019933	cAMP-mediated signaling
GO:0019934	cGMP-mediated signaling
GO:0030224	monocyte differentiation
GO:0033159	negative regulation of protein import into nucleus, translocation
GO:0035690	cellular response to drug
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0043116	negative regulation of vascular permeability
GO:0043117	positive regulation of vascular permeability
GO:0046069	cGMP catabolic process
GO:0071321	cellular response to cGMP
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0048471	perinuclear region of cytoplasm