InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPEN

Summary

InnateDB Gene

IDBG-91161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPEN

Gene Name

spen homolog, transcriptional regulator (Drosophila)

Synonyms

HIAA0929; MINT; RBM15C; SHARP

Species

Homo sapiens

Ensembl Gene

ENSG00000065526

Encoded Proteins

IDBP-91163

spen homolog, transcriptional regulator (Drosophila)

IDBP-371262

spen homolog, transcriptional regulator (Drosophila)

IDBP-371268

spen homolog, transcriptional regulator (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:15847864-15940460

Strand

Forward strand

Band

p36.21

Transcripts

ENST00000375759	ENSP00000364912
ENST00000438066	ENSP00000388021
ENST00000442985	ENSP00000400914
ENST00000471538
ENST00000487496

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	43 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001085	RNA polymerase II transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003676	nucleic acid binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0016032	viral process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050769	positive regulation of neurogenesis

Cellular Component

GO:0005634	nucleus
GO:0017053	transcriptional repressor complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040761

View Gene Order

ENSBTAG00000018729

Not yet available

Pathways

NETPATH

NetPath_3

Notch pathway

REACTOME

KEGG

INOH

PID NCI

hes_heypathway

Notch-mediated HES/HEY network

notch_pathway

Notch signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

23013

UniGene

Hs.558463 Hs.607981 Hs.727228

RefSeq

NM_015001

HUGO

HGNC:17575

OMIM

613484

CCDS

CCDS164

HPRD

10230

IMGT

EMBL

GenPept

RNA Seq Atlas

23013