InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Inppl1

Summary

InnateDB Gene

IDBG-202184.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Inppl1

Gene Name

inositol polyphosphate phosphatase-like 1

Synonyms

51C; SHIP2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032737

Encoded Proteins

IDBP-202186

inositol polyphosphate phosphatase-like 1

IDBP-626207

inositol polyphosphate phosphatase-like 1

IDBP-790142

inositol polyphosphate phosphatase-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165458:
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
The protein encoded by this gene is an SH2-containing 5\'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:101822632-101838076

Strand

Reverse strand

Band

Transcripts

ENSMUST00000035836	ENSMUSP00000048057
ENSMUST00000165052	ENSMUSP00000132883
ENSMUST00000186316
ENSMUST00000185929	ENSMUSP00000139910

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0017124	SH3 domain binding
GO:0042169	SH2 domain binding

Biological Process

GO:0001958	endochondral ossification
GO:0002376	immune system process
GO:0006006	glucose metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006897	endocytosis
GO:0007015	actin filament organization
GO:0007155	cell adhesion
GO:0008285	negative regulation of cell proliferation
GO:0009791	post-embryonic development
GO:0010629	negative regulation of gene expression
GO:0032868	response to insulin
GO:0044255	cellular lipid metabolic process
GO:0046856	phosphatidylinositol dephosphorylation
GO:0097178	ruffle assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0030027	lamellipodium
GO:0030175	filopodium