InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: INPPL1

Summary

InnateDB Gene

IDBG-635082.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INPPL1

Gene Name

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019167

Encoded Proteins

IDBP-686910

inositol polyphosphate phosphatase-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165458:
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
The protein encoded by this gene is an SH2-containing 5\'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:52609012-52623088

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025510

ENSBTAP00000025510

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042169	SH2 domain binding

Biological Process

GO:0001958	endochondral ossification
GO:0006006	glucose metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006897	endocytosis
GO:0007015	actin filament organization
GO:0008285	negative regulation of cell proliferation
GO:0009791	post-embryonic development
GO:0010629	negative regulation of gene expression
GO:0032868	response to insulin
GO:0044255	cellular lipid metabolic process
GO:0046856	phosphatidylinositol dephosphorylation
GO:0097178	ruffle assembly