InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIM21

Summary

InnateDB Gene

IDBG-24923.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM21

Gene Name

tripartite motif containing 21

Synonyms

RNF81; Ro/SSA; RO52; SSA; SSA1

Species

Homo sapiens

Ensembl Gene

ENSG00000132109

Encoded Proteins

IDBP-24925

tripartite motif containing 21

IDBP-591777

tripartite motif containing 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20627395

TRIM21 (Ro52) conjugates phosphorylated IKBKB with monoubiquitin and the IKBKB-induced NFkappa B signalling is downregulated. TRIM21-mediated monoubiquitination is involved in the subcellular translocation of active IKBKB to autophagosomes.

PMID 20668674

TRIM21 is a member of the TRIM family of single-protein E3 ligases and TRIM21-mediated ubiquitination promotes the degradation of IRF7 following TLR7 and TLR9 stimulation. As TRIM21 is also IFN-inducible, this system constitutes a negative-feedback loop that acts to protect the host from the prolonged activation of the immune response.

PMID 22479513

Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.

PMID 23438823

TRIM21 was identified in a systematic screen for positive regulators of innate immune responses.

InnateDB Annotation from Orthologs

Summary

PMID 22479513

[Mus musculus] Tyrosine phosphorylation of the E3 ubiquitin ligase Trim21 positively regulates interaction with Irf3 and hence Trim21 activity.

Entrez Gene

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:4384897-4393696

Strand

Reverse strand

Band

p15.4

Transcripts

ENST00000254436	ENSP00000254436
ENST00000533692	ENSP00000434053

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	85 [view]
Protein-Protein	84 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006513	protein monoubiquitination
GO:0007049	cell cycle
GO:0016567	protein ubiquitination
GO:0031648	protein destabilization
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032479	regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0032897	negative regulation of viral transcription
GO:0045087	innate immune response (InnateDB)
GO:0045787	positive regulation of cell cycle
GO:0046598	positive regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865	protein autoubiquitination
GO:0070206	protein trimerization
GO:0090086	negative regulation of protein deubiquitination
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex
GO:0030529	ribonucleoprotein complex