InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rxrg

Summary

InnateDB Gene

IDBG-203320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rxrg

Gene Name

retinoid X receptor gamma

Synonyms

Nr2b3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015843

Encoded Proteins

IDBP-203322

retinoid X receptor gamma

IDBP-258252

retinoid X receptor gamma

IDBP-258254

retinoid X receptor gamma

IDBP-258256

retinoid X receptor gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143171:
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:167598384-167639623

Strand

Forward strand

Band

H2.3

Transcripts

ENSMUST00000015987	ENSMUSP00000015987
ENSMUST00000111386	ENSMUSP00000107017
ENSMUST00000111384	ENSMUSP00000107015
ENSMUST00000111380	ENSMUSP00000107011

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004886	9-cis retinoic acid receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007422	peripheral nervous system development
GO:0007507	heart development
GO:0007519	skeletal muscle tissue development
GO:0014070	response to organic cyclic compound
GO:0030182	neuron differentiation
GO:0031641	regulation of myelination
GO:0032526	response to retinoic acid
GO:0032870	cellular response to hormone stimulus
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048384	retinoic acid receptor signaling pathway