Version 5.4
Homo sapiens Gene: TNNT3
Summary
InnateDB Gene IDBG-20352.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNT3
Gene Name troponin T type 3 (skeletal, fast)
Synonyms TNTF
Species Homo sapiens
Ensembl Gene ENSG00000130595
Encoded Proteins
IDBP-20354
troponin T type 3 (skeletal, fast)
IDBP-20356
troponin T type 3 (skeletal, fast)
IDBP-20358
troponin T type 3 (skeletal, fast)
IDBP-20360
troponin T type 3 (skeletal, fast)
IDBP-20366
troponin T type 3 (skeletal, fast)
IDBP-20368
troponin T type 3 (skeletal, fast)
IDBP-20374
troponin T type 3 (skeletal, fast)
IDBP-235620
troponin T type 3 (skeletal, fast)
IDBP-235622
troponin T type 3 (skeletal, fast)
IDBP-361610
troponin T type 3 (skeletal, fast)
IDBP-361633
troponin T type 3 (skeletal, fast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:1919562-1938706
Strand Forward strand
Band p15.5
Transcripts
ENST00000381589 ENSP00000371001
ENST00000381579 ENSP00000370991
ENST00000381563 ENSP00000370975
ENST00000344578 ENSP00000344870
ENST00000381558 ENSP00000370970
ENST00000381557 ENSP00000370969
ENST00000278317 ENSP00000278317
ENST00000397304 ENSP00000380471
ENST00000397301 ENSP00000380468
ENST00000453458 ENSP00000415614
ENST00000446240 ENSP00000413203
ENST00000492075
ENST00000493234
ENST00000473100
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005523 tropomyosin binding
GO:0030172 troponin C binding
GO:0030899 calcium-dependent ATPase activity
GO:0031013 troponin I binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006200 ATP catabolic process
GO:0006937 regulation of muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0030049 muscle filament sliding
GO:0043462 regulation of ATPase activity
Cellular Component
GO:0005829 cytosol
GO:0005861 troponin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061723
View Gene Order
ENSBTAG00000022158
Not yet available
Pathways
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P45378
TrEMBL A6NN42 C9JCA5 C9JZN9 F8WA37 H2KMD6 H2KMD7 H2KMD8 H9KVA2
UniProt Splice Variant
Entrez Gene 7140
UniGene
RefSeq NM_001042780 NM_001042781 NM_001042782 NM_001297646 NM_006757 XM_006718291 XM_006718292 XM_006718293 XM_006718294 XM_006718295 XM_006718296 XM_006718297 XM_006718298 XM_006718299 XM_006718300 XM_006718301 XM_006718302
HUGO HGNC:11950
OMIM 600692
CCDS CCDS41594 CCDS41595 CCDS41596 CCDS7727
HPRD
IMGT
EMBL AC051649 AF026276 AK056968 BC050446 BC117327 BC143537 BC171727 BT019997 BX640689 CR541927 DQ778624 JN864077 JN864078 JN864079 M21984 U14641 U14642 U14643 U14644
GenPept AAA36777 AAA50359 AAA50360 AAA50361 AAA50362 AAF21629 AAH50446 AAI17328 AAI43538 AAI71727 AAV38800 ABG77458 AEX92024 AEX92025 AEX92026 BAG51835 CAE45814 CAG46725
RNA Seq Atlas 7140

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca