Version 5.4
Bos taurus Gene: TNNT3
Summary
InnateDB Gene IDBG-645251.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNT3
Gene Name Troponin T, fast skeletal muscle
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000022158
Encoded Proteins
IDBP-697962
Troponin T, fast skeletal muscle
IDBP-697964
Troponin T, fast skeletal muscle
IDBP-697966
Troponin T, fast skeletal muscle
IDBP-697967
Troponin T, fast skeletal muscle
IDBP-697970
Troponin T, fast skeletal muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130595:
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:50218484-50233948
Strand Reverse strand
Band
Transcripts
ENSBTAT00000064506 ENSBTAP00000054396
ENSBTAT00000008422 ENSBTAP00000008422
ENSBTAT00000008371 ENSBTAP00000008371
ENSBTAT00000029890 ENSBTAP00000029885
ENSBTAT00000064427 ENSBTAP00000054320
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005523 tropomyosin binding
GO:0030172 troponin C binding
GO:0030899 calcium-dependent ATPase activity
GO:0031013 troponin I binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006200 ATP catabolic process
GO:0006937 regulation of muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0043462 regulation of ATPase activity
Cellular Component
GO:0005861 troponin complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000130595
View Gene Order
ENSMUSG00000061723
View Gene Order
Pathways
NETPATH
REACTOME
REACT_213099
Muscle contraction pathway
REACT_223821
Striated Muscle Contraction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
REACT_232053
Striated Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8MKI3
TrEMBL
UniProt Splice Variant
Entrez Gene 282096
UniGene Bt.11215
RefSeq XM_005227282 XM_005227286 NM_001001441 XM_005227283 XM_005227284 XM_005227285 XM_005227287 XM_005227289 XM_005227290 XM_005227291 XM_005227292 XM_005227293 XM_005227294
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB085593
GenPept BAB92976
RNA Seq Atlas 282096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca