Version 5.4
| Mus musculus Gene: Dut | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-203573.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Dut | ||||||||||
| Gene Name | deoxyuridine triphosphatase | ||||||||||
| Synonyms | 5031412I06Rik; 5133400F09Rik; D2Bwg0749e; Dutp; dUTPase | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000027203 | ||||||||||
| Encoded Proteins |
deoxyuridine triphosphatase
deoxyuridine triphosphatase
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128951:
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 2:125247190-125258608 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | F1 | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME | |||||||||||
| KEGG |
Pyrimidine metabolism pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME | |||||||||||
| KEGG |
Pyrimidine metabolism pathway
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| INOH |
Pyrimidine nucleotides nucleosides metabolism pathway
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| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | |||||||||||
| UniGene | |||||||||||
| RefSeq | NM_001159646 NM_023595 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS16675 CCDS50695 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | |||||||||||
| MGI Symbol | |||||||||||
| EMBL | |||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | |||||||||||