Version 5.4
Bos taurus Gene: DUT
Summary
InnateDB Gene IDBG-646681.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUT
Gene Name deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011998
Encoded Proteins
IDBP-699508
deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128951:
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:62284071-62295576
Strand Reverse strand
Band
Transcripts
ENSBTAT00000031441 ENSBTAP00000031396
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
Biological Process
GO:0046080 dUTP metabolic process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000128951
View Gene Order
ENSMUSG00000027203
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
mmu00240
Pyrimidine metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL Q2NKU1
UniProt Splice Variant
Entrez Gene 507945
UniGene Bt.11936
RefSeq NM_001077873
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111641 DAAA02029124
GenPept AAI11642
RNA Seq Atlas 507945

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca