InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cux1

Summary

InnateDB Gene

IDBG-204525.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cux1

Gene Name

cut-like homeobox 1

Synonyms

CDP; Cutl1; Cux; Cux-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029705

Encoded Proteins

IDBP-204529

cut-like homeobox 1

IDBP-725054

IDBP-724880

IDBP-724836

IDBP-725135

IDBP-724935

IDBP-725126

IDBP-725214

IDBP-724823

IDBP-725045

IDBP-725200

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000257923:
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:136248135-136567490

Strand

Reverse strand

Band

Transcripts

ENSMUST00000004097	ENSMUSP00000004097
ENSMUST00000163906
ENSMUST00000176172	ENSMUSP00000135086
ENSMUST00000176745	ENSMUSP00000135512
ENSMUST00000175998	ENSMUSP00000135816
ENSMUST00000176216	ENSMUSP00000135054
ENSMUST00000176423	ENSMUSP00000135036
ENSMUST00000175975	ENSMUSP00000135223
ENSMUST00000176501
ENSMUST00000176778	ENSMUSP00000135892
ENSMUST00000176486	ENSMUSP00000135370
ENSMUST00000175918	ENSMUSP00000135606
ENSMUST00000177297	ENSMUSP00000134819
ENSMUST00000177305

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0030674	protein binding, bridging
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000301	retrograde transport, vesicle recycling within Golgi
GO:0001822	kidney development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006891	intra-Golgi vesicle-mediated transport
GO:0030324	lung development
GO:0042491	auditory receptor cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030173	integral component of Golgi membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000257923

View Gene Order

ENSBTAG00000010659

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_121141

Signaling by FGFR1 fusion mutants pathway

REACT_121398

Signaling by FGFR mutants pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_120999

Signaling by FGFR1 mutants pathway

REACT_116125

Disease pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.320317 Mm.409729 Mm.471349

RefSeq

NM_001291234 NM_001291238 NM_001291239 NM_001291240 NM_009986 NM_198602 XM_006504355 XM_006504356 XM_006504359

OMIM

CCDS

CCDS39328 CCDS57391 CCDS71684 CCDS71685

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas