Version 5.4
Homo sapiens Gene: CUX1
Summary
InnateDB Gene IDBG-547448.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CUX1
Gene Name cut-like homeobox 1
Synonyms CASP; CDP; CDP/Cut; CDP1; Clox; COY1; CUTL1; CUX; Cux/CDP; GOLIM6; Nbla10317; p100; p110; p200; p75
Species Homo sapiens
Ensembl Gene ENSG00000257923
Encoded Proteins
IDBP-33363
cut-like homeobox 1
IDBP-33367
cut-like homeobox 1
IDBP-33369
cut-like homeobox 1
IDBP-242823
cut-like homeobox 1
IDBP-384299
cut-like homeobox 1
IDBP-384306
cut-like homeobox 1
IDBP-586727
cut-like homeobox 1
IDBP-601504
cut-like homeobox 1
IDBP-584179
cut-like homeobox 1
IDBP-590722
cut-like homeobox 1
IDBP-596523
cut-like homeobox 1
IDBP-810384
cut-like homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:101815904-102283957
Strand Forward strand
Band q22.1
Transcripts
ENST00000360264 ENSP00000353401
ENST00000292538 ENSP00000292538
ENST00000292535 ENSP00000292535
ENST00000393824 ENSP00000377410
ENST00000425244 ENSP00000409745
ENST00000437600 ENSP00000414091
ENST00000497815
ENST00000465461
ENST00000485792
ENST00000487284
ENST00000547394 ENSP00000449371
ENST00000549414 ENSP00000446630
ENST00000550008 ENSP00000447373
ENST00000546411 ENSP00000450125
ENST00000556210 ENSP00000451558
ENST00000558469
ENST00000560541
ENST00000558836
ENST00000622516 ENSP00000484760
ENST00000607092
ENST00000606749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001822 kidney development
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0007275 multicellular organismal development
GO:0030324 lung development
GO:0042491 auditory receptor cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050775 positive regulation of dendrite morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029705
View Gene Order
ENSBTAG00000010659
Not yet available
Pathways
NETPATH
REACTOME
REACT_121141
Signaling by FGFR1 fusion mutants pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_120999
Signaling by FGFR1 mutants pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.191482 Hs.611405 Hs.614266 Hs.614308 Hs.617164 Hs.699554 Hs.707744
RefSeq NM_001202543 NM_001202544 NM_001202545 NM_001202546 NM_001913 NM_181500 NM_181552 XM_005250150 XM_005250151 XM_005250154 XM_006715855
HUGO
OMIM
CCDS CCDS47672 CCDS56498 CCDS56499 CCDS56500 CCDS5720 CCDS5721 CCDS59071
HPRD 00295
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca